miRNA Plasmid Construction
Product Details:
| Place of Origin | Jiangsu, China |
|---|---|
| Brand Name | Biomicsus |
Payment & Shipping Terms:
| Minimum Order Quantity: | Production according to custom's requirement |
|---|---|
| Packaging Details: | as requested |
| Delivery Time: | delivery as soon as possible |
| Payment Terms: | T/T,Preis and Payment negotiable |
Detailed Product Description
miRNA biogenesis:
An miRNA gene is transcribed, generally by RNA polymerase II (PolII), generating the primary miRNA (pri-miRNA). In the nucleus, the RNase III endonuclease Drosha and the double-stranded RNA-bindingdomain (dsRBD) protein DGCR8/Pasha cleave the pri-miRNA to produce a2-nt 3'overhang containing the ~70-nt precursor miRNA (pre-miRNA).Exportin-5 transports the pre-miRNA into the cytoplasm, where it iscleaved by another RNase III endonuclease, Dicer, together with thedsRBD protein TRBP/Loquacious, releasing the 2-nt 3'overhang containinga ~21-nt miRNA:miRNA* duplex. The miRNA strand is loaded into anArgonaute-containing RNA-induced silencing complex (RISC), whereas themiRNA* strand is typically degraded.
The vector-based miRNA technology includes: customer provides the miRNAsequences, reliable DNA oligo synthesis, custom miRNA plasmidconstruction, ready plasmid DNA preparation, plasmid DNA sequencing,deliver the products.
miRNA Plasmid Construction
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Company Info
Biomics Biotechnologies Co., Ltd.
[China]
[Verified Member]
City: Nantong
Province/State: Jiangsu
Country/Region : China
Business Type:Manufacturer
Online Postings: Products